Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate

32160702

NA.41

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a membrane-anchored heavy chain and a light chain (beta-2 microglobulin). HLA class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen and are expressed in nearly all cells. HLA-B7 is an HLA-B serotype. B7, previously HL-A7, is a serotype that identifies the more common HLA-B*07 gene products and was one of the first ′HL-A′ antigens recognized. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.
BIOCHEMISTRY: p I = 6.3

Binds to the HLA-B7 antigen. It does not bind to HLA-B27 or other related HLA antigens.

Cell type Reactivity
Homozygous HLA-B7 ++
Heterozygous HLA-B7 +
Heterozygous HLA-B27 -
Non-HLA-B7, B27 -

Papain solubilized HLA-B7 antigen1

This Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate is validated for use in FC for the detection of HLA-B7.
Research Sub Category
Immunoglobulins & Immunology
Flow cytometry - Use 10 μL direct from the vial per 100 μL of whole blood, or 1 x 10E6 peripheral blood mononuclear cells (PBMC) in 100 μL buffer.

Optimal working concentrations must be determined by the end user.
Research Category
Inflammation & Immunology

Protein A purified
Purified mouse immunoglobulin in phosphate buffered saline, pH 7.4, containing 0.2% bovine Serum albumin and 0.1% sodium azide.

Control
Widely expressed

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

100

mouse

PE

purified immunoglobulin

primary antibodies

BB7.1, monoclonal

human

Chemicon^®

flow cytometry: suitable

IgG1

NM_005514.5

P03989

wet ice

Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2