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Anti-GPR Antibody3
| 产品编号： | 4108375 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-GPR Antibody3
G-protein coupled receptor 3, ACCA orphan receptor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | G-protein coupled receptor 3 (GPR3) is a member of the G-protein coupled receptor 1 family that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer ′s disease (AD). GPR3 has been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human GPR3. |
| Application【应用】 | Detect GPR using this rabbit polyclonal antibody, Anti-GPR Antibody3 validated for use in western blotting, IHC & Immunofluorescence. Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected GPR3 in human spleen tissue. Immunofluorescence Analysis: 20 µg/mL from a representative lot detected GPR3 in human spleen cells. Research Category Neuroscience Research Sub Category Neurodegenerative Diseases |
| Quality【质量】 | Evaluated by Western Blotting in EL4 cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected GPR3 in 15 µg of EL4 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control EL4 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P46089 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... GPR3(2827) |
产品说明
| Target description【目标描述】 | ~35 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
