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Anti-GATA-6 Antibody
产品编号: | 4108073 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-GATA-6 Antibody
Transcription factor GATA-6, GATA-binding factor 6
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | GATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs. GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes. GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart. Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels. Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels. Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the affects of pulmonary hypertension and other vascular syndromes is a subject of much research. |
Specificity【特异性】 | Recognizes GATA-6 |
Immunogen【免疫原】 | Set of 3 peptides designed against isoform 1 located between position 250-500). Note that peptide sequences used are also present in the isoform 2. Epitope: Region between amino acid positions 250-500. |
Application【应用】 | Research Sub Category Transcription Factors Immunocytochemistry Analysis: A representative lot of this antibody has been reported to detect GATA-6 in HeLa, 293T, Capan-2, and SH-SY5Ycells. Research Category Epigenetics & Nuclear Function This Anti-GATA-6 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of GATA-6. |
Quality【质量】 | Evaluated by Western Blotting in PC3 cell lysate. Western Blotting Analysis: A 2 µg/mL dilution of this antibody detected GATA-6 in PC3cell lysate. |
Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide. Antigen Affinity Purified |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human |
technique(s) | immunocytochemistry: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_005248 |
UniProt accession no.【UniProt登记号】 | Q92908 |
shipped in【运输】 | wet ice |
Gene Information | human ... GATA6(2627) |
产品说明
Target description【目标描述】 | ~ 62 kDa observed |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |