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Anti-GATA-6 Antibody

产品编号:4108073
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4108073100 μG4840
产品别名

Anti-GATA-6 Antibody

Transcription factor GATA-6, GATA-binding factor 6

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
GATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs. GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes. GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart. Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels. Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels. Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the affects of pulmonary hypertension and other vascular syndromes is a subject of much research.
Specificity【特异性】
Recognizes GATA-6
Immunogen【免疫原】
Set of 3 peptides designed against isoform 1 located between position 250-500). Note that peptide sequences used are also present in the isoform 2.
Epitope: Region between amino acid positions 250-500.
Application【应用】
Research Sub Category
Transcription Factors
Immunocytochemistry Analysis: A representative lot of this antibody has been reported to detect GATA-6 in HeLa, 293T, Capan-2, and SH-SY5Ycells.
Research Category
Epigenetics & Nuclear Function
This Anti-GATA-6 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of GATA-6.
Quality【质量】
Evaluated by Western Blotting in PC3 cell lysate.

Western Blotting Analysis: A 2 µg/mL dilution of this antibody detected GATA-6 in PC3cell lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Antigen Affinity Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_005248
UniProt accession no.【UniProt登记号】
Q92908
shipped in【运输】
wet ice
Gene Information
human ... GATA6(2627)
产品说明
Target description【目标描述】
~ 62 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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