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Anti-GABA-B receptor 2 Antibody, clone N81/37
产品别名
Anti-GABA-B receptor 2 Antibody, clone N81/37
GABA-B-R2, GABA-BR2, GABABR2, Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, Gb2, G-protein coupled receptor 51
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. |
Specificity【特异性】 | This antibody does not cross react with GABABR1 (Prof. J. Trimmer, University of California, Davis). |
Immunogen【免疫原】 | Recombinant protein corresponding to rat GABA-B receptor 2. |
Application【应用】 | Anti-GABA-B receptor 2 Antibody, clone N81/37 is a highly specific mouse monoclonal antibody, that targets GABA B Receptor & has been tested in western blotting & IHC. Western Blotting Analysis: 2.0 µg/mL from a representative lot detected GABA-B receptor 2 in 10 µg of mouse brain tissue lysate. Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GABA-B receptor 2 in human cerebellum and rat cerebral cortex tissue. Research Category Neuroscience Research Sub Category Developmental Signaling |
Quality【质量】 | Evaluated by Western Blotting in rat brain tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected GABA-B receptor 2 in 10 µg of rat brain tissue lysate. |
Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified antibody |
antibody product type | primary antibodies |
clone【克隆】 | N81/37, monoclonal |
species reactivity | rat, mouse, human |
technique(s) | immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_113990 |
UniProt accession no.【UniProt登记号】 | O88871 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~105 kDa observed |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |