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产品别名
Anti-FoxP2 Antibody
forkhead box P2, trinucleotide repeat containing 10, CAG repeat protein 44, forkhead/winged-helix transcription factor, Trinucleotide repeat-containing gene 10 protein, speech and language disorder 1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders. |
Specificity【特异性】 | This antibody recognizes FoxP2. |
Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to mouse FoxP2. Epitope: Unknown |
Application【应用】 | Research Category Epigenetics & Nuclear Function Neuroscience Research Sub Category Transcription Factors Neurodegenerative Diseases Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC. Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates. Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.) |
Quality【质量】 | Evaluated by Western Blot in RAW264.7 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate. |
Physical form【外形】 | Unpurified rabbit polyclonal serum with 0.05% sodium azide. Unpurified |
Analysis Note【分析说明】 | Control RAW264.7 cell lysate |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | serum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
species reactivity | human, mouse, rabbit |
technique(s) | immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG |
NCBI accession no.【NCBI登记号】 | NP_444472 |
UniProt accession no.【UniProt登记号】 | P58463 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | 80 and 77 kDa Observed. Alternative splicing can result in cell type dependent isoforms. |
Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |