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Anti-FBPase 1, clone 13A8.1 Antibody
产品别名
Anti-FBPase 1, clone 13A8.1 Antibody
Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets. |
Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human FBPase 1. |
Application【应用】 | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue. Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin). |
Quality【质量】 | Evaluated by Western Blotting in mouse stomach tissue lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate. |
Physical form【外形】 | Purified by Ion-Exchange Chromatography Format: Purified |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 13A8.1, monoclonal |
species reactivity | mouse, human |
technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
isotype【同位素/亚型】 | IgMκ |
NCBI accession no.【NCBI登记号】 | NP_000498 |
UniProt accession no.【UniProt登记号】 | P09467 |
shipped in【运输】 | wet ice |
Gene Information | human ... FBP1(2203) |
产品说明
Target description【目标描述】 | ~36 kDa observed. Uncharacterized band(s) may appear in some lysates. |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |