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产品别名
Anti-ERR-alpha P2 Antibody
Estrogen receptor-like 1, Estrogen-related receptor, alpha, Nuclear receptor subfamily 3 group B member 1, estrogen-related receptor alpha
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | ERR alpha is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has also been shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD),and thyroid hormone receptor genes. ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in brain, spinal cord, pituitary gland and heart. More recently, ERR alpha has been observed in various human breast cancer cell lines, breast adipose tissue and breast tumors. Studies demonstrating the use of ERR alpha antagonists in treating breast cancer have excited great interest in this receptor in the search for curing the disease (Chisamore, 2009). |
| Specificity【特异性】 | This antibody recognizes ERR-alpha. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human ERR-alpha. |
| Application【应用】 | Use Anti-ERR-alpha P2 Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect ERR-alpha P2 also known as Estrogen receptor-like 1, Estrogen-related receptor alpha. Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected ERR-alpha in A431 and HeLa cells. |
| Quality【质量】 | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 2 µg/mL of this antibody detected ERR-alpha on 10 µg of HeLa cell lysate. |
| Linkage【联系】 | Replaces: 04-1134 |
| Physical form【外形】 | Protein A purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | mouse, human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_004442 |
| UniProt accession no.【UniProt登记号】 | P11474 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 53 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
