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Anti-EPS8, Antibody
| 产品编号： | 4107500 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-EPS8, Antibody
Epidermal growth factor receptor kinase substrate 8, EPS8
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | EPS8 (epidermal growth factor receptor kinase substrate 8), which was originally identified as a substrate for the kinase activity of EGFR, is a multifunctional protein that is known to play a role in spermatogenesis, the regulation of actin, and other cellular processes. EPS8 uses its SH3 domain to complex with Abi1 and SOS1, leading to Rac activation and subsequent actin cytoskeletal remodeling. In the same manner, it binds with RN-tre to inhibit the internalization of EGFR. EPS8 also works with Arp3 to modulate actin dynamics within the seminiferous epithelium at the apical ES and the BTB. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human EPS8. |
| Application【应用】 | Research Sub Category Apoptosis - Additional This EPS8 antibody is validated for use in WB for the detection of the EPS8 protein. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blot in NIH/3T3 cell lysate. Western Blot Analysis: 0.2 µg/mL of this antibody detected EPS8 in 10 µg of NIH/3T3 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control NIH/3T3 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (immunogen homology), rat (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004438 |
| UniProt accession no.【UniProt登记号】 | Q12929 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... EPS8(2059) |
产品说明
| Target description【目标描述】 | ~97 kDa observed. A second isoform is known to exist at ~68 kDa Uncharacterized bands may be observed at ~50 kDa and ~37 kDa in some cell lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
