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Anti-EPAC2 Antibody
| 产品编号： | 4107462 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-EPAC2 Antibody
Rap guanine nuclear exchange factor 4, RAPGEF4, cAMPGEF-II, CGEF2, Exchange factor directly activated by cAMP 2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Exchange factor directly activated by cAMP 2 (EPAC2), also known as Rap guanine nuclear exchange factor 4 (RAPGEF4) and cAMP-regulated guanine nucleotide exchange factor II (cAMPGEF-II), belong to a family of cyclic adenosine monophosphate (cAMP) binding proteins that act as a guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B, and RAP2A small GTPases that are activated through cAMP binding. EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, exocytosis and inflammation. EPAC2 has been found to induce synapse remodeling and depression, with mutations in its gene being found in patients with autism. EPAC2 is predominantly expressed in brain and adrenal gland. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human EPAC2. |
| Application【应用】 | Anti-EPAC2 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC. Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected EPAC2 in mouse liver tissue. Research Category Neuroscience Research Sub Category Developmental Neuroscience |
| Quality【质量】 | Evaluated by Western Blotting/Peptide Inhibition Assay in rat liver tissue lysate. Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected EPAC2 in 15 µg of rat liver tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Rat liver tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q8WZA2 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... RAPGEF4(11069) |
产品说明
| Target description【目标描述】 | ~129 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~79 kDa, ~100 kDa, and ~116 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
