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Anti-DPAGT1 Antibody
产品编号: | 4107184 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-DPAGT1 Antibody
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, also known as GlcNAc-1-P transferase (G1PT or GPT) or N-acetylglucosamine-1-phosphate transferase, and encoded by the gene name DPAGT1 or DPAGT2, is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. Mutations in this integral endoplasmic reticulum (ER) membrane protein enzyme belongs to the glycosyltransferase family 4 results in the congenital disorder of glycosylation type Ij with symptoms such as severe hypotonia, medically intractable seizures, mental retardation, microcephaly, and exotropia. Recent experiments have shown that DPAGT1 is a target of the Wnt/beta-catenin signaling pathway, with Wnt3a inducing higher DPAGT1 mRNA expression. |
Immunogen【免疫原】 | KLH-conjugated synthetic peptide corresponding to the N-terminus of human DPAGT1. Epitope: N-terminus |
Application【应用】 | Research Category Signaling Anti-DPAGT1 Antibody detects level of DPAGT1 & has been published & validated for use in DPAGT1. Research Sub Category Developmental Signaling |
Quality【质量】 | Evaluated by Western Blotting in mouse kidney tissue lysate with and without blocking peptide. Western Blotting Analysis: 1 μg/mL of this antibody detected DPAGT1 in mouse kidney tissue lysate with and without blocking peptide. |
Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | mouse |
technique(s) | western blot: suitable |
UniProt accession no.【UniProt登记号】 | Q9H3H5 |
shipped in【运输】 | wet ice |
Gene Information | human ... DPAGT1(1798) |
产品说明
Target description【目标描述】 | ~42 kDa observed. Uncharacterized bands may be observed in some lysate(s). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |