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Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
产品别名
Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
Dbh
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Dopamine Beta Hydroxylase (DBH), the structural locus encoding DβH enzyme, is a major quantitative trait locus influencing plasma DβH activity, with one single nucleotide polymorphism (SNP) accounting for up to 50% of the variance. Mutations at DBH appear to be responsible for the rare syndrome of DβH deficiency. It functions as the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. |
Specificity【特异性】 | Dopamine beta hydroxylase (DBH). |
Immunogen【免疫原】 | Purified bovine DBH. |
Application【应用】 | Indirect immunofluorescence: 1:300-1:500 dilution of a previous lot was used on rat brain tissue. Optimal working dilutions must be determined by the end user. Immunohistochemistry(paraffin): Representative images from a previous lot. Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in IH, IH(P) & IF. |
Quality【质量】 | Immunohistochemistry(paraffin): Dopamine β Hydroxylase (cat. # MAB308) staining pattern/morphology in rat spinal cord. Tissue was pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:300, using IHC-Select Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord |
Linkage【联系】 | Replaces: MAB394-250UG; MAB394-100UG; MAB394-25UG |
Physical form【外形】 | Ascites mouse monoclonal IgG1 in liquid with 0.1% sodium azide. Unpurified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | ascites fluid |
antibody product type | primary antibodies |
clone【克隆】 | 4F10.2, monoclonal |
species reactivity | sheep, rat, bovine |
manufacturer/tradename | Chemicon® |
technique(s) | immunofluorescence: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
isotype【同位素/亚型】 | IgG1 |
NCBI accession no.【NCBI登记号】 | NM_000787.3 |
UniProt accession no.【UniProt登记号】 | P09172 |
shipped in【运输】 | dry ice |
产品说明
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | nwg |