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Anti-Cox-1, clone 5C5.1 Antibody

产品编号:4106592
规格:clone 5C5.1, 1 mg/mL, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4106592100 μG5520
产品别名

Anti-Cox-1, clone 5C5.1 Antibody

Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Cox-1, also known as Cytochrome C oxidase subunit 1, Cytochrome C oxidase polypeptide I, and encoded by the gene MT-CO1, CO1, COX1, MTCO1, is the catalytic subunit of Cytochrome C oxidase that forms the final reduction of oxygen to water in the respiratory chain. Subunits 1-3 form the functional core. Electrons originating in Cytochrome C are transferred via the copper A center of subunit 2 and the heme A of subunit 1 to the bimetallic center formed by the heme A3 and Copper B. The Cox-1 gene is encoded in the mitochondrion and the protein localizes to the inner mitochondrion membrane. It is expressed in all cells that contain functional mitochondria and mutations in Cox-1 are associated with various mitochondrial dysfunctional diseases that manifest themselves in defective vision, anemia, cardiomyopathy, muscle weakness and even some forms of cancer.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to human Cox-1.
Application【应用】
Detect Cox-1 using this Anti-Cox-1 antibody, clone 5C5.1 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Cox-1 in human thalamus, human kidney and human cerebellum tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Quality【质量】
Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Cox-1 in 10 µg of HeLa cell lysate.
Physical form【外形】
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
5C5.1, monoclonal
species reactivity
human
concentration【浓度】
1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
YP_003024028
UniProt accession no.【UniProt登记号】
P00395
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~65 kDa observed. Uncharacterized band(s) may appear in some lysates.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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