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Anti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2

产品编号:4106563
规格:clone 5A2, 1 mg/mL, from rat
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4106563100 μG5680
产品别名

Anti-C9ORF72/C9RANT (poly-GR) Antibody, clone 5A2

C9orf72

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Hexanucleotide (GGGGCC) repeat expansions in a noncoding region of C9ORF72 are the major genetic cause of FTD and ALS (c9FTD/ALS). The RNA structure of GGGGCC repeats renders these transcripts susceptible to an unconventional mechanism of translation—repeat associated non-ATG (RAN) translation. Translation of the GGGGCC-repeat in all reading frames would result in three dipeptide-repeat (DPR) proteins poly-(Gly-Ala), poly-(Gly-Pro) and poly-(Gly-Arg). poly-GA and poly-GP proteins are extremely hydrophobic and may form intracellular aggregates
Specificity【特异性】
This antibody recognizes C9ORF72/C9RANT (poly-GR) and other proteins containing poly-GR sequence, such as the Epstein Barr virus protein EBNA2
Immunogen【免疫原】
Epitope: poly-GR
Linear peptide corresponding to Epstein-Barr Virus Nuclear Antigen 2 (ENBA2) containing GR repeat sequence.
Application【应用】
Immunohistochemistry Analysis: A representative lot detected poly-GR inclusions from brain tissues of C9orf72 patients with C9ORF72 hexanucleotide expansion (Mori, K., et al. (2013). Science. 339(6125):1335-1338.).
Research Category
Neuroscience
Detect C9ORF72/C9RANT (poly-GR) using this Anti-C9ORF72/C9RANT (poly-GR) antibody, clone 5A2 validated for use in western blotting & IHC.
Research Sub Category
Neurodegenerative Diseases
Quality【质量】
Evaluated by Western Blotting using GST fusion proteins with 15 GA, GP, or GR repeats, as well as GST alone without any repeat sequence.

Western Blotting Analysis: 0.2 μg of this antibody detected 10 μg of GR-GST recombinant protein with 15 GR repeats.
Physical form【外形】
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
rat
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
5A2, monoclonal
species reactivity
human
species reactivity (predicted by homology)
all
concentration【浓度】
1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG2aκ
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
Variable
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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