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Anti-CHRDL1 Antibody, clone 10C9.3
产品别名
Anti-CHRDL1 Antibody, clone 10C9.3
Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Chordin-like protein 1 (CHRDL1) is an important secreted developmental mediator protein expressed in developing cornea, retina, brain, cerebellum and neocortex and developing bone. CHRDL1 in the nervous system alters the fate commitment of neural stem cells from gliogenesis to neurogenesis and contributes to neuronal differentiation of neural stem cells in the brain by the preventing the adoption of a glial fate. CHRDL1 also plays a critical role in dorsventral axis formation and regulates the action of BMP4 and preventing it from interacting with its receptors. In the developing eye CHRDL1 regulates retinal angiogenesis and the development of the anterior segment of the eye. Mutations in CHRDL1 are associated with various eye disorders and in particular one named Megalocornea 1, an X-linked developmental disease. |
Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human CHRDL1. |
Application【应用】 | Research Category Neuroscience This Anti-CHRDL1 Antibody, clone 10C9.3 is validated for use in Western Blotting and Immunohistochemistry for the detection of CHRDL1. |
Quality【质量】 | Evaluated by Western Blotting in rat brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected CHRDL1 in 200 µg of rat brain tissue lysate. |
Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
Analysis Note【分析说明】 | Control Western Blotting Analysis: 1.0 µg/mL from a representative lot detected CHRDL1 in 200 µg of human brain tissue lysate. Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CHRDL1 in human retina, human cerebellum, rat cerebellum, and rat cerebral cortex tissue. |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 10C9.3, monoclonal |
species reactivity | human, rat |
technique(s) | immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_001137453 |
UniProt accession no.【UniProt登记号】 | Q9BU40 |
shipped in【运输】 | wet ice |
Gene Information | human ... CHRDL1(91851) |
产品说明
Target description【目标描述】 | ~65 kDa observed. The calculated molecular weight of this protein is 50 kDa, but can be observed at ~65 kDa due to high glycosylation. |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |