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Anti-CD127 (IL-7Ra) Antibody (mouse), APC, clone A7R34
产品别名
Anti-CD127 (IL-7Ra) Antibody (mouse), APC, clone A7R34
Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM). |
| Immunogen【免疫原】 | Immunogen information for this antibody is proprietary information. |
| Application【应用】 | This Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), APC, clone A7R34, Cat. No. MABF378 is validated for use in IP, IHC, FC for the detection of CD127 (IL-7Ra). Research Category Inflammation & Immunology |
| Physical form【外形】 | Size Exclusion Chromatography Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | Allophycocyanin conjugate |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | A7R34, monoclonal |
| species reactivity | mouse |
| concentration【浓度】 | 0.2 mg/mL |
| technique(s) | flow cytometry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| UniProt accession no.【UniProt登记号】 | Q60943 |
| shipped in【运输】 | wet ice |
产品说明
| Storage and Stability【储存及稳定性】 | It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
