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Anti-BIN1 antibody produced in goat

产品编号:4105394
规格:affinity isolated antibody, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4105394100 μG4610
产品别名

Anti-BIN1 antibody produced in goat

Anti-DKFZp547F068

Anti-AMPHL

Anti-MGC10367

Anti-bridging integrator 1

Anti-AMPH2

基本信息
MDL number
MFCD01633055
NACRES
NA.41
General description【一般描述】
Bridging integrator 1 (BIN1) is mapped to human chromosome 2q14.3 and comprises 20 exons. The gene encodes multiple splice variants as close to 10 isoforms. Isoform nine and 10 are ubiquitous, eight is expressed in muscle. Rest other isoforms are expressed in brain. BIN1 comprises N-terminal BAR (Bin1/Amphiphysin/RVS167) domain and C-terminal SRC homology 3 (SH3) domain. It belongs to BAR superfamily and is a membrane deforming protein.
Immunogen【免疫原】
Peptide with sequence C-SDNAPAKGNKSPS from the internal region of the protein sequence according to NP_004296.1; NP_647593.1; NP_647594.1; NP_647595.1; NP_647596.1; NP_647597.1; NP_647598.1; NP_647599.1; NP_647600.1; NP_647601.1.
Biochem/physiol Actions【生化/生理作用】
Bridging integrator 1 (BIN1) mediates the endosomal vesicle sorting. It also modulates β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and regulates amyloid Aβ production. BIN1 interacts with actin through the BAR domain and also regulates tubulation of T?tubules and clathrin?mediated endocytosis. Single nucleotide polymorphisms in BIN1 and its altered expression is implicated in the pathogenesis of Alzheimer′s disease. Mutations in the BAR domain of the BIN1 leads impairment in T-tubule organization in centronuclear myopathy (CNM).
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
产品性质
biological source【生物来源】
goat
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
mouse, bovine, human, rat
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
O00499
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... BIN1(274)
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315 - H319
Precautionary Statements
P305 + P351 + P338
Hazard Classifications【危险分类】
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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