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Anti-BIN1 antibody produced in goat
产品编号: | 4105394 |
规格: | affinity isolated antibody, buffered aqueous solution |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-BIN1 antibody produced in goat
Anti-DKFZp547F068
Anti-AMPHL
Anti-MGC10367
Anti-bridging integrator 1
Anti-AMPH2
基本信息
MDL number | MFCD01633055 |
NACRES | NA.41 |
General description【一般描述】 | Bridging integrator 1 (BIN1) is mapped to human chromosome 2q14.3 and comprises 20 exons. The gene encodes multiple splice variants as close to 10 isoforms. Isoform nine and 10 are ubiquitous, eight is expressed in muscle. Rest other isoforms are expressed in brain. BIN1 comprises N-terminal BAR (Bin1/Amphiphysin/RVS167) domain and C-terminal SRC homology 3 (SH3) domain. It belongs to BAR superfamily and is a membrane deforming protein. |
Immunogen【免疫原】 | Peptide with sequence C-SDNAPAKGNKSPS from the internal region of the protein sequence according to NP_004296.1; NP_647593.1; NP_647594.1; NP_647595.1; NP_647596.1; NP_647597.1; NP_647598.1; NP_647599.1; NP_647600.1; NP_647601.1. |
Biochem/physiol Actions【生化/生理作用】 | Bridging integrator 1 (BIN1) mediates the endosomal vesicle sorting. It also modulates β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and regulates amyloid Aβ production. BIN1 interacts with actin through the BAR domain and also regulates tubulation of T?tubules and clathrin?mediated endocytosis. Single nucleotide polymorphisms in BIN1 and its altered expression is implicated in the pathogenesis of Alzheimer′s disease. Mutations in the BAR domain of the BIN1 leads impairment in T-tubule organization in centronuclear myopathy (CNM). |
Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
Physical form【外形】 | Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin. |
产品性质
biological source【生物来源】 | goat |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
species reactivity | mouse, bovine, human, rat |
technique(s) | indirect ELISA: suitable western blot: suitable |
UniProt accession no.【UniProt登记号】 | O00499 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... BIN1(274) |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H315 - H319 |
Precautionary Statements | P305 + P351 + P338 |
Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 |
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |