您的位置:首页 > 产品中心 > Anti-Betacellulin Antibody, clone 6G10.1
Anti-Betacellulin Antibody, clone 6G10.1
产品别名
Anti-Betacellulin Antibody, clone 6G10.1
Probetacellulin, Betacellulin, BTC
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment. |
Specificity【特异性】 | Clone 6G10.1 is expected to detect prepro-, pro-, and mature betacellulin. |
Immunogen【免疫原】 | Epitope: Mature betacellulin GST-tagged human recombinant full-length mature betacellulin. |
Application【应用】 | This Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin . Research Category Signaling Research Sub Category Signaling Neuroscience Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Betacellulin in human pancreas tissue. |
Quality【质量】 | Evaluated by Western Blotting in human pancreas tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Betacellulin in 10 µg of human pancreas tissue lysate. |
Physical form【外形】 | Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 6G10.1, monoclonal |
species reactivity | human |
technique(s) | immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_001720 |
UniProt accession no.【UniProt登记号】 | P35070 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~20 kDa observed. Preprobetacellulin (19.7 kDa calculated); Probetacellulin (16.6 kDa calculated); Betacellulin (9.0 kDa calculated). Due to posttranslational glycosylation, target band(s) will migrate with a higher apparent M.W. than caluclated. |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |