Anti-Beta-mannosidase Antibody, clone 1B3.1

32160702

NA.41

Beta-mannosidase, also known as Lysosomal beta A mannosidase or Mannanase, or Mannase, and encoded by the gene MANBA/MANB1, is an exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Beta-mannosidase is localized to the lysosome. Beta-mannosidase is expressed in many cell types including fibroblasts, neutrophils and even neurons and glia. Defects in Beta-mannosidase may be associated with a mild disorder that affects peripheral and central nervous system myelin health and is called Mannosidoisis beta A. It is a lysosomal storage disorder that results in a mixture of clinical features from mental retardation, hearing loss and speech activities.

KLH-conjugated linear peptide corresponding to human Beta-mannosidase.

Research Sub Category
Signaling Neuroscience
Research Category
Neuroscience
Anti-Beta-mannosidase Antibody, clone 1B3.1 is a highly specific mouse monoclonal antibody, that targets Mannosidase & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Beta-mannosidase in human cerebral cortex tissue.

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Beta-mannosidase in 10 µg of HepG2 cell lysate.

Format: Purified
Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

100

mouse

purified immunoglobulin

primary antibodies

1B3.1, monoclonal

human

immunohistochemistry: suitable (paraffin)
western blot: suitable

IgG1κ

NP_005899

O00462

wet ice

~80 kDa observed. The calculated molecular weight of this protein is 100 kDa However, this protein undergoes post-translational modification, and may be observed at ~110 kDa, ~100 kDa, ~91 kDa, ~86 kDa, ~84 kDa, and ~75 kDa (Sopher, B. L., et al. (1993). Biochem J. 289(Pt 2):343-347.).

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1