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Anti-beta Arrestin 1 Antibody, clone 3H11.2
产品别名
Anti-beta Arrestin 1 Antibody, clone 3H11.2
Retinal S-antigen, Rod photoreceptor arrestin, S-antigen, retina and pineal gland (arrestin), arrestin 1, retinal S-antigen (48 KDa protein)
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001). |
| Specificity【特异性】 | Other species have not been tested. Reacts with human beta-arrestin 1. |
| Immunogen【免疫原】 | KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1. Epitope: a.a. 357-372 |
| Application【应用】 | Research Category Cell Structure Research Sub Category Sensory & PNS G-proteins Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF. |
| Quality【质量】 | Evaluated on a representative lot by Western blot in HEK293 cell lysate. |
| Physical form【外形】 | Purified in PBS with 0.05% NaN3. Format: Purified Ammonium Sulfate Precipitation |
| Analysis Note【分析说明】 | Control HEK293 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| clone【克隆】 | 3H11.2, monoclonal |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgMκ |
| NCBI accession no.【NCBI登记号】 | NP_004032.2 |
| UniProt accession no.【UniProt登记号】 | P49407 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~47 kDa |
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
