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Anti-Amyloid, β 1-40, aβ Antibody

产品编号:4104851
规格:from rabbit, purified by affinity chromatography
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4104851100 μL6190
产品别名

Anti-Amyloid, β 1-40, aβ Antibody

Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, 1.N-APP2.Soluble APP-alpha, S-APP-alpha3.Soluble APP-beta, S-APP-beta4.C995.Beta-amyloid protein 42, Be

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.
Specificity【特异性】
This antibody recognizes the P3(40) peptide of Amyloid, β 1-40.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.
Epitope: P3(40) peptide
Application【应用】
Research Category
Neuroscience
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer′s diseased brain tissue.

ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).
Research Sub Category
Neurodegenerative Diseases
Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.
Quality【质量】
Evaluated by Western Blot in human Alzheimer brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.
Linkage【联系】
Replaces: AB5737
Physical form【外形】
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Analysis Note【分析说明】
Control
Human Alzhiemer brain tissue lysate
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001129601
UniProt accession no.【UniProt登记号】
P05067
shipped in【运输】
wet ice
Gene Information
human ... APP(351)
产品说明
Target description【目标描述】
~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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