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Anti-ADE2 Antibody/SAICAR synthetase
产品编号: | 4104633 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-ADE2 Antibody/SAICAR synthetase
Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Multifunctional protein ADE2, which is encoded by the gene name PAICS, ADE2, AIRC, PAIS, is a member of the SAICAR synthetase family and the AIR carboxylase family. Multifunctional protein ADE2 includes the following two domains: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), and Phosphoribosylaminoimidazole carboxylase (AIR carboxylase/ AIRC). ADE2 is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. ADE2 is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for ADE2. ADE2/ PAICS (phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase) is a protein-coding gene. Diseases associated with ADE2 include androgen insensitivity syndrome, and pseudohermaphroditism, and among its related super-pathways are Metabolic pathways and Purine metabolism. |
Immunogen【免疫原】 | Epitope: SAICAR synthetase KLH-conjugated linear peptide corresponding to human ADE2/SAICAR synthetase. |
Application【应用】 | This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2. |
Quality【质量】 | Evaluated by Western Blotting in TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected ADE2/SAICAR synthetase in 10 µg of TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate. |
Other Notes【其他说明】 | Affinity purified |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | rat (based on 100% sequence homology), mouse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), feline (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), canine (based on 100% sequence homology) |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_001072992 |
UniProt accession no.【UniProt登记号】 | P22234 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~47 kDa observed. Uncharacterized band(s) may appear in some lysates. |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |