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Anti-ADE2 Antibody/SAICAR synthetase

产品编号:4104633
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4104633100 μG5420
产品别名

Anti-ADE2 Antibody/SAICAR synthetase

Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Multifunctional protein ADE2, which is encoded by the gene name PAICS, ADE2, AIRC, PAIS, is a member of the SAICAR synthetase family and the AIR carboxylase family. Multifunctional protein ADE2 includes the following two domains: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), and Phosphoribosylaminoimidazole carboxylase (AIR carboxylase/ AIRC). ADE2 is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. ADE2 is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for ADE2. ADE2/ PAICS (phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase) is a protein-coding gene. Diseases associated with ADE2 include androgen insensitivity syndrome, and pseudohermaphroditism, and among its related super-pathways are Metabolic pathways and Purine metabolism.
Immunogen【免疫原】
Epitope: SAICAR synthetase
KLH-conjugated linear peptide corresponding to human ADE2/SAICAR synthetase.
Application【应用】
This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2.
Quality【质量】
Evaluated by Western Blotting in TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected ADE2/SAICAR synthetase in 10 µg of TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.
Other Notes【其他说明】
Affinity purified
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
rat (based on 100% sequence homology), mouse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), feline (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), canine (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001072992
UniProt accession no.【UniProt登记号】
P22234
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~47 kDa observed. Uncharacterized band(s) may appear in some lysates.
【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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