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Anti-ADAP Antibody

产品编号:4104623
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4104623100 μG4740
产品别名

Anti-ADAP Antibody

ADAP Antibody, Adhesion and degranulation adapter protein, FYN binding protein, FYB-120, 130, SLAP-130, FYN-T-binding protein, SLP-76-associated phosphoprotein

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The adhesion and degranulation adaptor protein (ADAP) acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. ADAP modulates the expression of interleukin-2 (IL-2) and it is suggested to be involved in platelet activation. Additionally ADAP is shown to prevent the degradation of SKAP1 and SKAP2 and may play a role in linking T-cell signaling to the remodeling of the actin cytoskeleton. ADAP is expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. At least two isoforms of ADAP are known to exist.
Specificity【特异性】
This antibody recognizes the C-terminus of ADAP.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP.
Epitope: C-terminus
Application【应用】
Research Category
Cell Structure
Detect ADAP using this rabbit polyclonal antibody, Anti-ADAP Antibody validated for use in western blotting & ICC.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected ADAP in K562 cells.
Research Sub Category
Adhesion (CAMs)
Quality【质量】
Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected ADAP in 15 µg of K562 cell lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
Analysis Note【分析说明】
Control
K562 cell lysate
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
technique(s)
immunocytochemistry: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
O15117
shipped in【运输】
wet ice
Gene Information
human ... FYB(2533)
产品说明
Target description【目标描述】
~130 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 2 isoforms at ~85 kDa and ~91 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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