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Anti-ABCA4 Antibody, clone 5D7.1
产品别名
Anti-ABCA4 Antibody, clone 5D7.1
Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Retinal-specific ATP-binding cassette transporter encoded by the gene ABCA4 plays a critical role in the transport of retinoid substrates from the extracellular or intradiscal rod cell membranes to the cytoplasmic membrane surface for processing ultimately into vitamin A and then transferred to the retinal pigment epithelium where it is converted to 11-cis-retinal that active component needed for vision. ABCA4 is localized to the outer segments of rods and cones with a million copies per photoreceptor. ABCA4 is retinal specific protein. Mutations in ABCA4 are linked to several eye-related genetic diseases, such as forms of macular degeneration called Stargardt disease and ARMD2, as well as Retinitis pigmentosa 19, and Cone-rod dystrophy 3. |
| Immunogen【免疫原】 | Recombinant protein corresponding to human ABCA4. |
| Application【应用】 | Anti-ABCA4 Antibody, clone 5D7.1 | MABN287 is an antibody against ABCA4 Antibody for use in Western Blotting, Immunohistochemistry (Paraffin). Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ABCA4 in human retina tissue. |
| Quality【质量】 | Evaluated by Western Blotting in Y79 cell lysate. Western Blotting Analysis: 5.0 µg/mL of this antibody detected ABCA4 in 200 µg of Y79 cell lysate. |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 5D7.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_000341 |
| UniProt accession no.【UniProt登记号】 | P78363 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~275 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
