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Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody

产品编号:4104402
规格:clone 7C7.1, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4104402100 μG5520
产品别名

Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody

26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1, 26S proteasome non-ATPase regulatory subunit 14

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
26S proteasome non-ATPase regulatory subunit 14 is also known as 26S proteasome regulatory subunit RPN11 or 26S proteasome-associated PAD1 homolog 1. This protein is expressed from the PSMD14 gene and is the metalloprotease component of the 26S proteasome that specifically cleaves ′Lys-63′-linked polyubiquitin chains. 26S proteasome non-ATPase regulatory subunit 14 has a role in the response to double-strand breaks (DSBs) by regulating non-homologous end joining (NHEJ) via cleaving ′Lys-63′-linked polyubiquitin, retaining JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 26S proteasome non-ATPase regulatory subunit 14 is also involved in homologous recombination repair by promoting RAD51 loading. 26S proteasome non-ATPase regulatory subunit 14 is widely expressed, but found in the highest levels in heart and skeletal muscle.
Specificity【特异性】
Recognizes 26S proteasome regulatory subunit RPN11
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to 26S proteasome regulatory subunit RPN11.
Epitope: Region near N-terminus
Application【应用】
Research Sub Category
Chromatin Biology

Cell Cycle, DNA Replication & Repair
This Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of 26S proteasome regulatory subunit RPN11.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 26S proteasome regulatory subunit RPN11 in human cardiac myocytes and rat skelatal muscle myocytes.
Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function
Quality【质量】
Evaluated by Western Blotting in HT-1080 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected 26S proteasome regulatory subunit RPN1 in 10 µg of HT-1080 cell lysate.
Physical form【外形】
Format: Purified
Purified mouse monoclonal IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
7C7.1, monoclonal
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype【同位素/亚型】
IgG2bκ
NCBI accession no.【NCBI登记号】
NP_005796
UniProt accession no.【UniProt登记号】
O00487
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~ 35 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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