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产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | liquid |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | 1.06 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:200 western blot: 1:500-1:2000 |
| UniProt accession no.【UniProt登记号】 | Q96LA8 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRMT6(55170) |
基本信息
| General description【一般描述】 | The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. |
| Immunogen【免疫原】 | Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human PRMT6 (NP_060607.2). |
| Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
