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产品别名
Anti-NOTCH1 antibody produced in rabbit
AOVD1
NOTCH1
HN1
AOS5
Activated NOTCH1
TAN1
notch 1
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 272 |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | 1 mg/ml |
| technique(s) | immunofluorescence: 1:50-1:200 immunohistochemistry: 1:100-1:200 western blot: 1:500-1:2000 |
| UniProt accession no.【UniProt登记号】 | P46531 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... NOTCH1(4851) |
基本信息
| General description【一般描述】 | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. |
| Immunogen【免疫原】 | A synthetic peptide of human NOTCH1 |
| Physical form【外形】 | PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
产品说明
| Storage and Stability【储存及稳定性】 | Store at -20℃. Avoid freeze / thaw cycles. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
