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ANG-2 Protein, Human Recombinant

产品编号:4104143
规格:Angiopoietin2 (Ang-2) is a secreted glycoprotein that plays a complex role in angiogenesis & inflammation.
包装规格:20 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410414320 μG4640
产品别名

ANG-2 Protein, Human Recombinant

ANG2, ANG, Angiopoietin 2, ANGPT2

基本信息
eCl@ss
32160405
General description【一般描述】
Product Source: CHO Cells
Angiopoietin2 (Ang-2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang-2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an α helix rich “coiled coil” N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.
Specificity【特异性】
Cross Reactivty
None
Application【应用】
Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Quality【质量】
Bioactivity assay: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC). Bioactivity assay: Determined by its ability to stimulate tubulogenesis in HUVEC cells using a concentration of 0.2μg/ml.
Physical form【外形】
Product is filtered through a 0.2 micron filter before lyophilization.
产品性质
Quality Level【质量水平】
100
Assay【测定】
>95% (SDS-PAGE and HPLC)
impurities【杂质】
<0.1 μg/mg protein endotoxin (<1EU/μg)
UniProt accession no.【UniProt登记号】
O15123
shipped in【运输】
dry ice
产品说明
Storage and Stability【储存及稳定性】
Store at -20°C for up to 6 months from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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