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Agrin Human

产品编号:4103913
规格:Recombinant, cell culture tested, expressed in HEK 293 cells
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410391350 μG4260
产品别名

Agrin Human

AGRN

Proteoglycan

产品性质
recombinant【重组】
expressed in HEK 293 cells
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
lyophilized powder
potency【效能】
attachment assay, measured by the ability of the immobilized agrin to support the adhesion of PC12 cells
technique(s)
cell culture | mammalian: suitable
suitability【适用性】
endotoxin tested
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
基本信息
General description【一般描述】
Agrin C-terminal human recombinant is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 87 kDa (amino acids Ala1260-Pro2045, with an N-terminal His tag). The DTT-reduced protein migrates as a ∼100 kDa polypeptide on SDS-PAGE due to glycosylation. This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher bioactivity of the protein.
Biochem/physiol Actions【生化/生理作用】
Agrin is a large extracellular heparan sulfate proteoglycan that is involved in the formation of the neuromuscular junction.
Agrin triggers the aggregation of acetylcholine receptors via the muscle-specific kinase (MuSK) and the low-density lipoprotein receptor-related protein 4 (Lrp4) receptor complex.
Agrin is required for the full regenerative capacity of neonatal mouse hearts.
Recombinant agrin has been shown in vitro to promote cardiomyocyte proliferation, as studied in mouse-induced and human-induced pluripotent stem cells. Recombinant agrin has been shown in vivo to promote cardiac regeneration, after induction of myocardial infarction in adult mice.
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
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