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ADAM12 human

产品编号:4103882
规格:recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410388210 μG3780
产品别名

ADAM12 human

MLTN

MLTNA

MCMP

ADAM12

MCMPMltna

Meltrin Alpha

基本信息
NACRES
NA.32
General description【一般描述】
A Disintegrin And Metalloprotease 12 (ADAM12) is also known as Meltrin-α and MCMP, is a member of the ADAM and MDC (Metalloprotease, Disintegrin, Cysteine-rich) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. Over 30 members have been identified and about half of them are active metalloproteases such as ADAM8, 9, 10, 12 and 17/TACE. ADAM12 has four Isoform, Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. ADAM12 Involved in skeletal muscle regeneration, specifically at the onset of cell fusion and also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
Physical form【外形】
Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in HEK 293 cells
tag【标签】
6-His tagged (C-terminus)
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
lyophilized powder
mol wt【分子量】
calculated mol wt 34 kDa (Mature)
calculated mol wt 55.2 kDa
observed mol wt 23 kDa (DTT-reduced. Protein migrates due to glycosylation corresponding to the propeptide, the mature form and the pro form respectively. Leu24 is the predicted N-terminus.)
observed mol wt 46 kDa
observed mol wt 65 kDa
packaging【包装】
pkg of 10 μg
impurities【杂质】
<1 EU/μg endotoxin (LAL test)
NCBI accession no.【NCBI登记号】
ADAM12
UniProt accession no.【UniProt登记号】
O43184
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... ADAM12(8038)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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