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5′-Hydroxy carvedilol
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4103709 | 10 MG | 4930 | |||
4103709 | 50 MG | 24710 |
产品别名
142227-51-8
5′-Hydroxy carvedilol
5OHC
3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol
5-Hydroxycarvedilol
5′-Hydroxyphenylcarvedilol
BM-140830
5′-OH carvedilol
Carvedilol metabolite M5
5′-Hydroxyphenyl carvedilol
基本信息
Empirical Formula【经验(实验)分子式】 | C24H26N2O5 |
Molecular weight | 422.47 |
General description【一般描述】 | Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: soluble, clear, colorless |
storage temp.【储存温度】 | 2-8℃ |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |