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5′-Hydroxy carvedilol

产品编号:4103709
规格:≥95% (HPLC)
CAS NO:142227-51-8
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
410370910 MG4930
410370950 MG24710
产品别名

142227-51-8

5′-Hydroxy carvedilol

5OHC

3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol

5-Hydroxycarvedilol

5′-Hydroxyphenylcarvedilol

BM-140830

5′-OH carvedilol

Carvedilol metabolite M5

5′-Hydroxyphenyl carvedilol

基本信息
Empirical Formula【经验(实验)分子式】
C24H26N2O5
Molecular weight
422.47
General description【一般描述】
Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solid
color【颜色】
off-white
solubility【溶解性】
DMSO: soluble, clear, colorless
storage temp.【储存温度】
2-8℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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