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4EBP1,His 标记 人

4EBP1, His tagged human
产品编号:4103707
规格:recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
CAS NO:185703-54-2
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
410370750 μG4310
产品别名

185703-54-2

4EBP1,His 标记 人

4EBP1, His tagged human

MGC4316

BP-1

EIF4EBP1

PHAS-I

基本信息
NACRES
NA.32
General description【一般描述】
Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is part of the translation repressor protein family. The gene encoding it is localized on human chromosome 8p11-p12.
Biochem/physiol Actions【生化/生理作用】
Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is involved in protein synthesis, cell growth and survival. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Phosphorylation of E1F4EBP1 releases it from eukaryotic translation initiation factor 4E (eIF4E) and this results in cap-dependent translation. The protein is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It is also a substrate for mTORC1 (mammalian target of rapamycin complex 1). In non-phosphorylated conditions, E1F4EBP1 interacts with p21 (cyclin-dependent kinase inhibitor) and enhances destabilization of p21.
Physical form【外形】
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note【制备说明】
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in baculovirus infected Sf9 cells
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
mol wt【分子量】
~18 kDa
NCBI accession no.【NCBI登记号】
NM_004095
application(s)
cell analysis
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... EIF4EBP1(1978)
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H315 - H319 - H360D
Precautionary Statements
P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Classifications【危险分类】
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code【储存分类代码】
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
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