广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 1492-18-8, 亚叶酸钙
产品搜索:

亚叶酸钙

Calcium folinate for system suitability
产品编号:4100267
规格:European Pharmacopoeia (EP) Reference Standard
CAS NO:1492-18-8
包装规格:
产品类别:进口试剂
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4100267 1440
产品别名

1492-18-8

亚叶酸钙

Calcium folinate for system suitability

Leucovorin calcium salt

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt

5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt

Folinic Acid Calcium Salt Hydrate

Calcium folinate

5-HCO-H4PteGlu

Citrovorum factor calcium salt

5-甲酰基-5,6,7,8-四氢蝶酰基-L-谷氨酸 钙盐

叶醛酸钙

亚叶酸 钙盐 水合物

嗜橙菌因子 钙盐

甲酰四氢叶酸 钙盐

5-甲酰基-5,6,7,8-四氢叶酸 钙盐

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C20H21CaN7O7 · xH2O
Molecular weight
511.50 (anhydrous basis)
Beilstein
5723924
General description【一般描述】
Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application【应用】
Calcium folinate for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
叶酸拮抗剂通过结合二氢叶酸还原酶并阻滞叶酸转化为四氢叶酸盐发挥作用,而亚叶酸钙则可抵消叶酸拮抗剂的作用。在医学上,亚叶酸钙在甲氨蝶呤治疗后用于降低甲氨蝶呤的毒性。亚叶酸钙还可用于增强癌症治疗中 5-氟尿嘧啶的细胞毒性效应。
Other Notes【其他说明】
Sales restrictions may apply.
产品性质
biological source【生物来源】
synthetic
grade【等级】
pharmaceutical primary standard
agency
EP
form【形式】
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
pharmaceutical (small molecule)
format【格式】
neat
storage temp.【储存温度】
−20℃
SMILES string
[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
packaging【包装】
Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H315 - H317 - H319 - H334 - H335
Precautionary Statements
P261 - P264 - P280 - P280 - P304 + P340 + P312 - P342 + P311
Hazard Classifications【危险分类】
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0087