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Urocortin human

产品编号:4099893
规格:≥85% (HPLC), powder
CAS NO:176591-49-4
包装规格:250 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4099893250 μG6770
产品别名

176591-49-4

Urocortin human

基本信息
Empirical Formula【经验(实验)分子式】
C204H337N63O64
Molecular weight
4696.24
MDL number
MFCD00802621
NACRES
NA.32
Amino Acid Sequence
Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Application【应用】
Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
Biochem/physiol Actions【生化/生理作用】
Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
human
Assay【测定】
≥85% (HPLC)
form【形式】
powder
technique(s)
ligand binding assay: suitable
UniProt accession no.【UniProt登记号】
P55089
storage temp.【储存温度】
−20℃
Gene Information
human ... UCN(7349)
packaging【包装】
250 μg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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