Nocodazole-CAS 31430-18-9-Calbiochem

C₁₄H₁₁N₃O₃S

301.32

MFCD00005588

NA.77

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d<2 µM).

Product does not compete with ATP.
Reversible: no
Primary Target
Promotes tubulin depolymerization
Cell permeable: no

Toxicity: Carcinogenic / Teratogenic (D)

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (HPLC)

solid

Calbiochem^®

OK to freeze

pale yellow

DMSO: 5 mg/mL

ambient

10-30℃

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

KYRVNWMVYQXFEU-UHFFFAOYSA-N

10 mg in Plastic ampoule

GHS08

Warning

H341 - H361d

P201 - P202 - P280 - P308 + P313 - P405 - P501

Muta. 2 - Repr. 2

11 - Combustible Solids

WGK 3