您的位置:首页 > 产品中心 > Anti-Caspase 3 Antibody, large subunit &proform, clone 4-1-18
Anti-Caspase 3 Antibody, large subunit &proform, clone 4-1-18
产品别名
Anti-Caspase 3 Antibody, large subunit &proform, clone 4-1-18
CPP32
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
Specificity【特异性】 | Recognizes the full length 32 kDa caspase-3 protein. Highly specific to caspase-3 and shows no cross-reaction with other caspase family members. Caspase-3 is ubiquitously expressed and like other caspases is synthesized as an inactive proenzyme. Upon activation, caspase-3 is cleaved generating two smaller subunits of 17 kDa and 12 kDa. Caspase-3 is one of the most extensively studied enzyme in apoptosis. Activation of caspase-3 occurs in response to a variety of apoptotic inducers. |
Immunogen【免疫原】 | Recombinant full-length human caspase-3 protein Epitope: large subunit & proform |
Application【应用】 | Western blot: 1:1000. The antibody will detect a band at 32 kDa corresponding to the inactive unprocessed form of caspase 3 as well as a 17-22 kDa band corresponding to the large subunit of active caspase 3. Immunohistochemistry (frozen and paraffin): 1:500. Optimal working dilutions must be determined by end user. Research Sub Category Caspases Enzymes & Biochemistry Research Category Apoptosis & Cancer Metabolism Anti-Caspase 3 Antibody, large subunit & proform, clone 4-1-18 detects level of Caspase 3 & has been published & validated for use in WB, IH(P). |
Linkage【联系】 | Replaces: 04-439 |
Physical form【外形】 | Purified immunoglobulin by protein A. Liquid in PBS, pH 7.6, with 0.1% sodium azide. Format: Purified |
Analysis Note【分析说明】 | Control POSITIVE CONTROL: 293 (human embryonic kidney) cell lysates |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 4-1-18, monoclonal |
species reactivity | human |
manufacturer/tradename | Chemicon® |
technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
isotype【同位素/亚型】 | IgG2aκ |
NCBI accession no.【NCBI登记号】 | NM_004346.3 NM_032991.2 |
UniProt accession no.【UniProt登记号】 | P42574 |
shipped in【运输】 | wet ice |
Gene Information | human ... CASP3(836) |
产品说明
Storage and Stability【储存及稳定性】 | Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |