Rottlerin-CAS 82-08-6-Calbiochem

C₃₀H₂₈O₈

516.54

MFCD00017361

A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC₅₀ = 3-6 µM) and PKC_Θ isozymes. Also inhibits PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ξ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).
A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKC_δ (IC₅₀ = 3-6 µM) and PKC_θ. Inhibits the PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ζ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).

Cell permeable: yes
Product does not compete with ATP.
Primary Target
PKCδ
Reversible: yes
Target IC₅₀: 3-6 µM against PKCδ; 5.3 µM against CaM kinase III

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Villalba, M., et al. 1999. J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett.338, 85.
Gschwendt, M., et al. 1984. Cancer Lett.25, 177.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

orange

ethanol: 1 mg/mL
DMSO: 30 mg/mL

ambient

2-8℃

1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+

DEZFNHCVIZBHBI-ZHACJKMWSA-N

10 mg in Plastic ampoule

11 - Combustible Solids

WGK 3