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Anti-Tau Antibody, clone Tau 12
产品别名
Anti-Tau Antibody, clone Tau 12
G protein beta1/gamma2 subunit-interacting factor 1, Neurofibrillary tangle protein, Paired helical filament-tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. |
| Specificity【特异性】 | Reactivity with other species has not been determined. Cat. # MAB2241 recognizes the N-terminus region of Tau. |
| Immunogen【免疫原】 | KLH conjugated synthetic linear peptide. Epitope: N-terminus |
| Application【应用】 | Research Category Neuroscience Anti-Tau Antibody, clone Tau 12 is an antibody against Tau for use in WB. Research Sub Category Neurodegenerative Diseases |
| Quality【质量】 | Western Blot: |
| Linkage【联系】 | Replaces: MAB10417 |
| Physical form【外形】 | Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Human brain tissue lysate. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| clone【克隆】 | Tau 12, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| UniProt accession no.【UniProt登记号】 | P10636 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 50-68 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
