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Anti-Calponin-1 Antibody

产品编号:4096321
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4096321100 μG5850
产品别名

Anti-Calponin-1 Antibody

Calponin-1, Basic calponin, Calponin H1, smooth muscle

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Calponin 1 is a 34 kDa protein that is predominantly found in smooth muscle tissue. It is a high-affinity actin-binding protein, but also interacts with tropomyosin, and calmodulin to modulate muscle contraction. When bound to F-actin, it inhibits the activity of the actin-activated myosin ATPase. Calponin 1 is regulated by reversible phosphorylation involving PKC and CAMKII kinases, and type 2A phosphatases. In non-muscle cells, calponin 1 may play a role in cell migration, motility, and proliferation.
Specificity【特异性】
This antibody recognizes the C-terminus of Calponin-1.
Other homologies: Rat (92% sequence homology) and Mouse (83% sequence homology).
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to the C-terminus of human Calponin-1.
Epitope: C-terminus
Application【应用】
Research Category
Cell Structure
Immunohistochemistry Analysis: A 1:1,000 dilution from a reprsesentative lot detected Calponin-1 in human seminal vesicle tissue.

Immunofluorescence Analysis: A 1:500 dilution from a representative lot detected Calponin-1 in smooth muscle cells from human seminal vesicle tissue.
This Anti-Calponin-1 Antibody is validated for use in Western Blotting, IHC(P), Immunofluorescence for the detection of Calponin-1.
Research Sub Category
Cytoskeleton
Quality【质量】
Evaluated by Western Blot in human aortic smooth muscle tissue.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Calponin-1 in human aortic smooth muscle tissue.
Linkage【联系】
Replaces: 04-589
Physical form【外形】
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Analysis Note【分析说明】
Control
Human aortic smooth muscle tissue
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
chimpanzee (based on 100% sequence homology), sheep (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001290
UniProt accession no.【UniProt登记号】
P51911
shipped in【运输】
wet ice
Gene Information
human ... CNN1(1264)
产品说明
Target description【目标描述】
~33 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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