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Anti-Zic2 Antibody
| 产品编号： | 4096309 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Zic2 Antibody
Zic family member 2 (odd-paired Drosophila homolog), Zic family member 2 (odd-paired homolog, Drosophila), Zinc finger protein of the cerebellum 2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Zinc-finger transcription factor (Zic2) is a conserved signaling protein with critical roles in neural development including neurulation, anteroposterior patterning, neural crest formation, cerebellar development, and ipsilateral axonal targeting across the optic chiasm. It activates the transcription of target genes by DNA binding and recruitment of RNA helicase A (RHA). Zic2 has been shown to operate as a transcriptional repressor of cellular proliferation and neurogenesis. Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with markers of neurogenesis. The Zic2kd/kd mice show holoprosencephaly and spina bifida, which derive from malformations in the anterior and posterior ends of the neural tube, respectively. Due to its apparent role in the regulation of granule cell expansion, Zic2 expression is a useful marker for mature granule neurons in the developing cerebellum. |
| Specificity【特异性】 | This antibody recognizes Zic2. |
| Immunogen【免疫原】 | Epitope: This antibody recognizes Zic2 at the N-terminus region. This antibody is generated from rabbits immunized with a GST-tagged recombinant protein corresponding to residues in the N-terminus of mouse Zic2. |
| Application【应用】 | Immunohistochemistry Analysis: 1:200 dilution from a previous lot detected Zic2 on mouse cerebellum and hippocampus tissue. Anti-Zic2 Antibody is an antibody against Zic2 for use in WB, IH. |
| Quality【质量】 | Evaluated by Western Blot in mouse cerebellum lysate. Western Blot Analysis: : 0.1 µg/ml of this antibody detected Zic2 on 10 µg of mouse cerebellum lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology), monkey (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_033600 |
| UniProt accession no.【UniProt登记号】 | Q62520 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 55 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
