Anti-TNKS (N-terminal) antibody produced in goat

NA.41

The gene TNKS (tankyrase) is mapped to human chromosome 8p23.1. It belongs to the PARP (poly (ADP-ribose) polymerase) family of proteins and is responsible for addition of poly (ADP-ribose) (PAR) to substrate proteins. The TNKS protein contains ankyrin repeats and a sterile α-motif (SAM).

Peptide with sequence RECOMBINANT, from the N Terminal Region of the protein sequence according to NP_003738.2.

TNKS (tankyrase) is a regulator of Wnt-signaling. It negatively regulates Axin1, thereby suppressing β-catenin degradation and causing hyperactivation of Wnt/β-catenin signaling. TNKS controls cell death and telomere length. It might also be associated with osteoarthritis. In murine lung cancer model, silencing of this gene reduces lung cancer cell growth. Application of TNKS inhibitor suppresses growth of hepatocellular carcinoma cells. Absence of TNKS activity helps in replication of human cytomegalovirus (HCMV).

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

100

goat

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

western blot: suitable

O95271

dry ice

−20℃

human ... TNKS(8658)

12 - Non Combustible Liquids

WGK 2