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Anti-MORF4 Antibody
| 产品编号： | 4096276 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-MORF4 Antibody
MORF4 Antibody, MORF4, Mortality factor 4, Cellular senescence-related protein 1, SEN1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Mortality factor 4 (MORF4) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes typically by acetylation of nucleosomal histones H4 and H2A. NuA4 complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis. MORF4 is localized to the nucleus and has transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif. Additionally, MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human MORF4. |
| Application【应用】 | Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected MORF4 in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MORF4 in HepG2 cells. Research Sub Category Apoptosis - Additional Anti-MORF4 Antibody is a highly specific rabbit polyclonal antibody, that targets Mortality factor 4 & has been tested in western blotting, IHC & Immunofluorescence. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blotting in K562 cell lysate Western Blotting Analysis: 2 µg/mL of this antibody detected MORF4 in 15 µg of K562 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control K562 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q9UBU8 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~33 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
