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ROCK2 (5-554),活性,GST 标记 人

ROCK2 (5-554), active, GST tagged human
产品编号:4096155
规格:PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
409615510 μG5920
产品别名

ROCK2 (5-554),活性,GST 标记 人

ROCK2 (5-554), active, GST tagged human

ROCK-II

KIAA0619

ROKalpha

基本信息
MDL number
MFCD02688767
NACRES
NA.32
Biochem/physiol Actions【生化/生理作用】
ROCK2 is a ubiquitously expressed serine/threonine kinase localized in the nucleus that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. ROCK2 is an immediate downstream target of the small GTPase RhoA. ROCK2 may play a pivotal role in cardiovascular diseases such as vasospastic angina, ischemic stroke, and heart failure. Inhibition of ROCKs by statins or other selective inhibitors leads to the upregulation and activation of endothelial nitric oxide synthase (eNOS) and reduction of vascular inflammation and atherosclerosis.
Physical form【外形】
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information【法律信息】
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
产品性质
Quality Level【质量水平】
200
recombinant【重组】
expressed in baculovirus infected Sf9 cells
product line【产品线】
PRECISIO® Kinase
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
Specific Activity
298-403 nmol/min·mg
mol wt【分子量】
~88 kDa
UniProt accession no.【UniProt登记号】
O75116
relevant disease(s)【相关疾病】
cardiovascular diseases
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... ROCK2(9475)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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