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RO-52 (SSA) human

产品编号:4096153
规格:recombinant, expressed in E. coli, liquid
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4096153100 μG5050
基本信息
MDL number
MFCD03458409
NACRES
NA.56
General description【一般描述】
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Application【应用】
RO-52 (SSA) human has been used:
  • as a component of the autoantigen array
  • to immobilise protein on the self-assembly monolayer
  • in enzyme-linked immunosorbent assays (ELISAs)

Biochem/physiol Actions【生化/生理作用】
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
Physical form【外形】
solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.
产品性质
Quality Level【质量水平】
200
recombinant【重组】
expressed in E. coli
form【形式】
liquid
mol wt【分子量】
52 kDa by SDS-PAGE
technique(s)
ELISA: suitable
UniProt accession no.【UniProt登记号】
P19474
storage temp.【储存温度】
−70℃
Gene Information
human ... TRIM21(6737)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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