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RO-52 (SSA) human
产品编号: | 4096153 |
规格: | recombinant, expressed in E. coli, liquid |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
基本信息
MDL number | MFCD03458409 |
NACRES | NA.56 |
General description【一般描述】 | RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE. |
Application【应用】 | RO-52 (SSA) human has been used:
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Biochem/physiol Actions【生化/生理作用】 | Used for the detection and quantification of antibodies to RNPs in rheumatic diseases. |
Physical form【外形】 | solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6. |
产品性质
Quality Level【质量水平】 | 200 |
recombinant【重组】 | expressed in E. coli |
form【形式】 | liquid |
mol wt【分子量】 | 52 kDa by SDS-PAGE |
technique(s) | ELISA: suitable |
UniProt accession no.【UniProt登记号】 | P19474 |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... TRIM21(6737) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |