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PRKG1, active, GST tagged human
产品编号: | 4096150 |
规格: | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
PRKG1, active, GST tagged human
CGKI
DKFZp686K042
MGC71944
PGK
FLJ36117
基本信息
NACRES | NA.32 |
Biochem/physiol Actions【生化/生理作用】 | PRKG1 is a homodimer, with each monomer containing a regulatory cGMP-binding domain and a catalytic domain. By Northern blot analysis PRKG1 was shown to be expressed at highest levels in bladder, uterus, adrenal gland, and fallopian tube. PRKG1 plays an important stimulatory role in platelet activation. Expression of recombinant PRKG1 in a reconstituted cell model enhanced von Willebrand factor-induced activation of the platelet integrin alpha-IIb/beta-3. Prkg1 knockout mice showed impaired platelet responses to VWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by VWF or low-dose thrombin was inhibited by PRKG1 inhibitors but enhanced by cGMP. |
Physical form【外形】 | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
Quality Level【质量水平】 | 200 |
recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
product line【产品线】 | PRECISIO® Kinase |
Assay【测定】 | ≥70% (SDS-PAGE) |
form【形式】 | buffered aqueous glycerol solution |
Specific Activity | 663-897 nmol/min·mg |
mol wt【分子量】 | ~100 kDa |
UniProt accession no.【UniProt登记号】 | Q13976 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... PRKG1(5592) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |