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Anti-Syndecan-1 Antibody
产品别名
Anti-Syndecan-1 Antibody
CD138 antigen, heparan sulfate proteoglycan fibroblast growth factor
receptor, syndecan 1, syndecan proteoglycan 1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Syndecan-1, also known as CD138, is a transmembrane (Type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization. Bearing properties of both heparan sulfate and chondroitin sulfate, Syndecan-1 functions as a cell surface proteoglycan membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. |
Specificity【特异性】 | Reactivity with other species has not been tested. Predicted to cross react with human, based on 100% sequence homology. Cat. No. AB8230 recognizes mouse Syndecan-1. |
Immunogen【免疫原】 | His-tagged, full-length human recombinant Syndecan-1 protein. |
Application【应用】 | Research Category Cell Structure Anti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB. Research Sub Category ECM Proteins |
Quality【质量】 | Evaluated on a representative lot by Western blot on mouse liver lysate using 1:1000 dilution of Anti-Syndecan-1. |
Physical form【外形】 | Rabbit serum containing 0.05% NaN3. |
Analysis Note【分析说明】 | Control Mouse liver lysate |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | serum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
species reactivity | human, mouse |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NM_001006946.1 |
UniProt accession no.【UniProt登记号】 | P18827 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | The expected molecular weight of monomeric Syndecan-1 is ~32 kDa; however, the core protein often migrates as an SDS-stable dimer with an approximate M.W. of 77 kDa Additionally, a high M.W. form of the protein may often be seen between 500-1000 kDa, likely the mature form of Syndecan-1, with all of its heparan and chondroitin sulfate additions. In whole tissues, this mature form often binds tightly to ECM molecules and may require solublization by urea extraction for additional SDS-PAGE analysis (Wilsie, 2006). Triton X-100 or similar mild detergents are sufficient to release the immature precursor forms of Syndecan-1. |
Storage and Stability【储存及稳定性】 | Maintain at -20°C for up to 1 year from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |