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AKT1, active, GST tagged human

产品编号:4096110
规格:PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
409611010 μG4690
产品别名

AKT1, active, GST tagged human

RAC

PKB

RAC-α

MGC99656

PRKBA

基本信息
NACRES
NA.32
General description【一般描述】
v-akt murine thymoma viral oncogene homolog 1 (AKT1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308. This gene is localized on human chromosome 14q32.32.
Biochem/physiol Actions【生化/生理作用】
v-akt murine thymoma viral oncogene homolog 1 (AKT1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis. Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.
Physical form【外形】
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note【制备说明】
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information【法律信息】
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
产品性质
recombinant【重组】
expressed in baculovirus infected Sf9 cells
product line【产品线】
PRECISIO® Kinase
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
Specific Activity
103-139 nmol/min·mg
mol wt【分子量】
~85 kDa
NCBI accession no.【NCBI登记号】
NM_005163
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... AKT1(207)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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