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Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE

产品编号:4096080
规格:clone AW39R, Milli-Mark®, from rabbit
包装规格:100 TESTS
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4096080100 TESTS4840
产品别名

Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE

Erk1

Erk2

p44-MAPK

p42-MAPK

MAPK2

PRKM2

p41mapk

PRKM1

p44

ERK2

P42MAPK

ERK

p42

MAPK1

ERT1

ERT2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted as Erk1 (p44, MAPK3) and Erk2 (p42, MAPK1) that both function in the same pathway. The two proteins are often referred to collectively as Erk1/2 or p44/p42 MAP kinase. The Erk pathway is considered the classical, canonical MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It is an evolutionarily conserved pathway that controls and is a critical regulator of the growth and survival through the promotion of cell proliferation and the prevention of apoptosis. Erk is involved in the control of many fundamental cellular processes including cell proliferation, survival, differentiation, apoptosis, motility and metabolism. Erk is activated by growth factor stimulation of receptor tyrosine kinases (RTKs), GPCR, and/or integrin stimulation. This activates the Ras-Raf-MEK-Erk pathway that results in the phosphorylation/activation of Erk1/2 (p44/p42) on the TxY motif (Thr202/Tyr204 and Thr185/Tyr187 for Erk1 & Erk2, respectively).
Specificity【特异性】
Antibody recognizes Recognizes Erk 1 & 2 only when dually phosphorylated on its TxY activation motif.
Immunogen【免疫原】
Phosphorylated recombinant peptide corresponding to amino acids surrounding the pTEpY motif in the activation loop of human phospho-Erk1/2, in which the Thr and Tyr residues are phosphorylated
Epitope: Phosphorylated Thr185/Phosphorylated Tyr187
Application【应用】
Research Sub Category
MAP Kinases
This Milli-Mark Phospho-Erk1/2 antibody is validated for use in Flow & WB for the detection of the Milli-Mark Phospho-Erk1/2 protein.
Research Category
Signaling
Quality【质量】
Evaluated by Flow Cytometry with Jurkat cells.
Physical form【外形】
Purified Rabbit monoclonal supernatant conjugated to phycoerythrin in buffer containing PBS with 0.05% sodium azide
Protein A purified
Analysis Note【分析说明】
Control
Jurkat Cells
Legal Information【法律信息】
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
PE
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
AW39R, monoclonal
species reactivity
rat, mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NP_002736.3
UniProt accession no.【UniProt登记号】
P28482
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
42kDa and 44kDa Observed
Storage and Stability【储存及稳定性】
Stable for 6 months at 2-8°C from date of receipt. Protect from light.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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