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Milli-Mark® Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18
产品编号: | 4096079 |
规格: | clone 69-10C-2-10C-18, Milli-Mark®, from rabbit |
包装规格: | 100 TESTS |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Milli-Mark® Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18
B-cell CLL/lymphoma 2
B-cell lymphoma protein 2
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | The Bcl name is derived from B-cell chronic lymphocytic leukemia, and was given to genes involved in that disease. Members of the Bcl-2 family share homologous domains (BH) through which they are able to homo- and hetero-dimerize. Bcl-2 plays an important role in cytochrome c release from the mitochondria; it also binds Apaf1, inhibiting Apaf-1 association with caspase-9. Bcl-2 overexpression in indicated in a number of human cancers, including melanoma, breast, prostate, and lung, and it correlates with resistance to cancer treatment (presumably due to decreased apoptosis). Bcl-2 has also been implicated in schizophrenia and autoimmune disorders. Bcl-2 phosphorylated at Ser-70 plays a critial role in the translocation of Bax from the cytosol to the mitochondria, and this may regulate NO-induced neuronal apoptosis. The molecular mechanism of Bcl-2 phosphorylation and its relationship to Bax is largely unknown. |
Specificity【特异性】 | This antibody recognizes phosphorylated Bcl-2 at Ser70. |
Immunogen【免疫原】 | Epitope: Ser70 KLH-conjugated linear peptide corresponding to human Bcl-2 phosphorylated at Ser70. |
Application【应用】 | Detect phospho-Bcl-2 (Ser70) using this Milli-Mark Anti-phospho-Bcl-2 Antibody, clone 69-10C-2-10C-18 validated for use in FC. Research Sub Category BCL2 & Inhibition Research Category Apoptosis & Cancer |
Quality【质量】 | Evaluated by flow cytometry using Jurkat cells. |
Physical form【外形】 | Purified rabbit monoclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. Protein A purified |
Analysis Note【分析说明】 | Control Jurkat cells. |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
conjugate【偶联物】 | PE |
antibody form【抗体形式】 | purified antibody |
antibody product type | primary antibodies |
clone【克隆】 | 69-10C-2-10C-18, monoclonal |
species reactivity | human |
manufacturer/tradename | Milli-Mark® |
technique(s) | flow cytometry: suitable |
isotype【同位素/亚型】 | IgG |
NCBI accession no.【NCBI登记号】 | NP_000624.2 |
UniProt accession no.【UniProt登记号】 | P10415 |
shipped in【运输】 | wet ice |
Gene Information | human ... BCL2(596) |
产品说明
Target description【目标描述】 | 26 kDa Observed |
Storage and Stability【储存及稳定性】 | Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |