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Milli-Mark® Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

产品编号:4096079
规格:clone 69-10C-2-10C-18, Milli-Mark®, from rabbit
包装规格:100 TESTS
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4096079100 TESTS4680
产品别名

Milli-Mark® Anti-phospho-Bcl-2 (Ser70) -PE Antibody, clone 69-10C-2-10C-18

B-cell CLL/lymphoma 2

B-cell lymphoma protein 2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The Bcl name is derived from B-cell chronic lymphocytic leukemia, and was given to genes involved in that disease. Members of the Bcl-2 family share homologous domains (BH) through which they are able to homo- and hetero-dimerize. Bcl-2 plays an important role in cytochrome c release from the mitochondria; it also binds Apaf1, inhibiting Apaf-1 association with caspase-9. Bcl-2 overexpression in indicated in a number of human cancers, including melanoma, breast, prostate, and lung, and it correlates with resistance to cancer treatment (presumably due to decreased apoptosis). Bcl-2 has also been implicated in schizophrenia and autoimmune disorders. Bcl-2 phosphorylated at Ser-70 plays a critial role in the translocation of Bax from the cytosol to the mitochondria, and this may regulate NO-induced neuronal apoptosis. The molecular mechanism of Bcl-2 phosphorylation and its relationship to Bax is largely unknown.
Specificity【特异性】
This antibody recognizes phosphorylated Bcl-2 at Ser70.
Immunogen【免疫原】
Epitope: Ser70
KLH-conjugated linear peptide corresponding to human Bcl-2 phosphorylated at Ser70.
Application【应用】
Detect phospho-Bcl-2 (Ser70) using this Milli-Mark Anti-phospho-Bcl-2 Antibody, clone 69-10C-2-10C-18 validated for use in FC.
Research Sub Category
BCL2 & Inhibition
Research Category
Apoptosis & Cancer
Quality【质量】
Evaluated by flow cytometry using Jurkat cells.
Physical form【外形】
Purified rabbit monoclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Protein A purified
Analysis Note【分析说明】
Control
Jurkat cells.
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
PE
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
69-10C-2-10C-18, monoclonal
species reactivity
human
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NP_000624.2
UniProt accession no.【UniProt登记号】
P10415
shipped in【运输】
wet ice
Gene Information
human ... BCL2(596)
产品说明
Target description【目标描述】
26 kDa Observed
Storage and Stability【储存及稳定性】
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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