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Anti-NMDAR2A Antibody
产品别名
Anti-NMDAR2A Antibody
N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor subunit 2A, NMDA receptor subtype 2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | NMDA (N-methyl-D-aspartate) receptors are a class of ionotropic glutamate receptors. The NMDAR channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). |
Specificity【特异性】 | NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes. Does not react with NMDAR2B or NMDAR2C. Immunolabeling is blocked by preadsorption of antibody with the immunogen. |
Immunogen【免疫原】 | Epitope: C-terminus C-Terminal Fusion Protein of rat NMDAR2A, aa 1253-1391. |
Application【应用】 | Immunoprecipitation: 3 μg of a previous lot was used to (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200 μg of rat brain. Immunohistochemistry: A previous lot of this antibody was used at 1:1,000-1:2,000 dilution. Optimal working dilutions must be determined by the end user. Research Category Neuroscience Anti-NMDAR2A Antibody is an antibody against NMDAR2A for use in IH, IP & WB. Research Sub Category Neurotransmitters & Receptors |
Quality【质量】 | Routinely evaluated by Western Blot on Rat Brain Microsomal lysates. Western Blot Analysis: 1:500 dilution of this lot detected NMDAR2A on 10 μg of Rat Brain Microsomal lysates. |
Physical form【外形】 | ImmunoAffinity Purified Purified rabbit polyclonal lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservative. |
Analysis Note【分析说明】 | Control NMDAR2A is present in high concentrations in the hippocampus. |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | fish, human, rat, mouse |
manufacturer/tradename | Chemicon® |
technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_000824 |
UniProt accession no.【UniProt登记号】 | Q12879 |
shipped in【运输】 | dry ice |
Gene Information | human ... GRIN2A(2903) |
产品说明
Target description【目标描述】 | 180 kDa |
Storage and Stability【储存及稳定性】 | Lyophilized material stable for 1 year at -20°C from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up 6 months. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |