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Anti-PRMT4 antibody produced in rabbit

产品编号:4095875
规格:~1 mg/mL, affinity isolated antibody, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4095875200 μL4610
产品别名

Anti-PRMT4 antibody produced in rabbit

Anti-Protein-Arginine Methyl Transferase 4

Anti-CARM1

基本信息
MDL number
MFCD05665250
NACRES
NA.41
General description【一般描述】
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
Immunogen【免疫原】
synthetic peptide corresponding to amino acids 48-63 of human PRMT4 conjugated to KLH via a C-terminal added lysine residue. The sequence is conserved in mouse.
Application【应用】
Anti-PRMT4 antibody produced in rabbit has been used for Western Blotting and immunofluorescence.
Biochem/physiol Actions【生化/生理作用】
Protein-arginine methyl transferase 4 (PRMT4) plays a central role in upregulation of transcription by nuclear hormone receptors (NRs).
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2α, a chromatin remodeler. It also associates with nuclear factor κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~50 kDa
species reactivity
human
concentration【浓度】
~1 mg/mL
technique(s)
immunoprecipitation (IP): 5-20 μg using PRMT4-fusion protein from extracts of transfected 293T cells.
microarray: suitable
western blot: 0.5-1 μg/mL using nuclear extracts of the MCF7 breast carcinoma cell line.
UniProt accession no.【UniProt登记号】
Q86X55
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CARM1(10498)
mouse ... Carm1(59035)
packaging【包装】
200 μL in glass insert
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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