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Anti-PRMT4 antibody produced in rabbit
产品编号: | 4095875 |
规格: | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-PRMT4 antibody produced in rabbit
Anti-Protein-Arginine Methyl Transferase 4
Anti-CARM1
基本信息
MDL number | MFCD05665250 |
NACRES | NA.41 |
General description【一般描述】 | Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2. |
Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 48-63 of human PRMT4 conjugated to KLH via a C-terminal added lysine residue. The sequence is conserved in mouse. |
Application【应用】 | Anti-PRMT4 antibody produced in rabbit has been used for Western Blotting and immunofluorescence. |
Biochem/physiol Actions【生化/生理作用】 | Protein-arginine methyl transferase 4 (PRMT4) plays a central role in upregulation of transcription by nuclear hormone receptors (NRs). Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2α, a chromatin remodeler. It also associates with nuclear factor κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 200 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~50 kDa |
species reactivity | human |
concentration【浓度】 | ~1 mg/mL |
technique(s) | immunoprecipitation (IP): 5-20 μg using PRMT4-fusion protein from extracts of transfected 293T cells. microarray: suitable western blot: 0.5-1 μg/mL using nuclear extracts of the MCF7 breast carcinoma cell line. |
UniProt accession no.【UniProt登记号】 | Q86X55 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... CARM1(10498) mouse ... Carm1(59035) |
packaging【包装】 | 200 μL in glass insert |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | nwg |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |